EXPERIMENTALLY VALIDATED OXIDATIVE STRESS -ASSOCIATED PROGNOSTIC SIGNATURES DESCRIBE THE IMMUNE LANDSCAPE AND PREDICT THE DRUG RESPONSE AND PROGNOSIS OF SKCM

BackgroundSkin Cutaneous Melanoma (SKCM) incidence is continually increasing, with chemotherapy and the gel bottle cashmere immunotherapy being among the most common cancer treatment modalities.This study aims to identify novel biomarkers for chemotherapy and immunotherapy response in SKCM and explore their association with oxidative stress.Methods

Combating health insurance fraud is of utmost importance equi-jec 7 to physicians, patients, and health insurers.To delve into the mechanisms of health insurance fraud between doctors and patients, this study employed evolutionary game theory to construct a model that comprehensively considers moral hazard, fraud cost, reward, punishment, bribes fr

Abstract Background The performance of 3D-based virtual screening similarity functions is affected by the applied conformations of compounds.Therefore, the results of 3D approaches are often less robust than 2D approaches.The application of 3D methods on multiple conformer data sets normally reduces this weakness, but entails a significant computat

Abstract In view of the fuzziness and randomness of the safety evaluation of the channel navigation environment, a crystal beaded candle holder risk evaluation model of the channel navigation is established with the set-valued statistics and the gray theory.A safety evaluation index system of channel navigation consisting of first-level indexes for